Lehner Lab
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Repositories
- MoCHI Public
Neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data
- Programmed_readthrough Public
Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs. Here we use deep mutational scanning to quantify ~1,400 sequence variants for each of the three examples of human readthrough in the genes AQP4, MAPK10 and OPRK1.
- allostery_pathogenicity Public
- OpenSplice Public
This repository contains all code to reproduce the analyses and figures in the OpenSplice paper. OpenSplice quantifies the impact of >590,000 variants on the splicing of 608 human exons using massively parallel site-saturation mutagenesis in minigene constructs.
- TF-MAPS Public
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins.
- PDZ_homologs Public
- pdzextms Public
Source code for analyses and to reproduce all figures in the following publication: The effects of PDZ domain extensions on energies, energetic couplings and allostery (Hidalgo-Carcedo C & Faure AJ et al., 2023)
- ABA_receptor Public Forked from MaximilianStammnitz/ABA_receptor
Companion scripts for DMS data processing, dose-response curve fitting and figure reproduction ("The genetic architecture of an allosteric hormone receptor", Stammnitz & Lehner, biorXiv 2025)
- src_allostery Public
Source code for analyses and to reproduce all figures in the following publication: The allosteric landscape of Src (Beltran et al., 2023)
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